Corneal Dystrophy and the
Cavalier King Charles Spaniel
- What It Is
- Related Disorders
- Breeders' Responsibilities
- What You Can Do
- Research News
- Related Links
- Veterinary Resources
Corneal dystrophy is a genetic disorder which is relatively common in cavalier King Charles spaniels.* It is the development of gray-white opaque deposits of calcium and fats under the surface of both of the dog's corneas. They usually appear in cavaliers between the ages of two and four years.
The form of corneal dystrophy most common among CKCSs is epithelial/stromal dystrophy, which describe the gray-white opacity which is visible in the dog's eyes. (See photo below at right.) This disorder may also be referred to as lipidosis. In the cavalier, it is believed to be caused by hyperlipoproteinemia, which is an inability to break down lipids or fats, particularly cholesterol and triglycerides, in the body.
In a 1993 report, Dr. Shiela Crispin found that, especially in the cavalier King Charles spaniel, crystalline stromal dystrophy due to hyperlipoproteinaemmia (raised HDL, LDL, and VLDL) is an ocular manifestation of Cushing's syndrome. (The photo at right, from Dr. Crispin's 1993 report, shows the eye of a cavalier with crystalline stromal dystrophy secondary to hyperlipoproteinaemia associated with Cushing’s syndome. The right eye is shown and the lipid is situated immediately lateral to the camera flash.)
All CKCSs should be examined at least annually by a board certified veterinary ophthalmologist. They are listed on the website of the American College of Veterinary Ophthalmologists (ACVO).
Corneal dystrophy has been recognized as a manifestation of Cushing's disease in the CKCS.
Corneal dystrophy usually does not affect vision, is not painful, and no treatment is necessary. In an abstract presented to the 2010 WSAVA Congress by Dr. Charlotte Keller, DACVO, DECVO, she suggests that treatment may include the reduction of fat intake.
However, since corneal dystrophy in the CKCS has been found to be a manifestation of Cushing's disease, testing for that disorder also should be performed.
Currently, the Canine Eye Registration Foundation (CERF) does not deny certification to cavalier King Charles spaniels which are affected with corneal dystrophy, because the Genetics Committee of the ACVO classifies the disorder as a "breeder option" for CKCSs. However, the Canine Inherited Disorders Database recommends that all dogs suffering from corneal dystrophy not be bred.
The Cavalier King Charles Spaniel Club, USA recommends that, prior to breeding any Cavalier, the dog have a normal rating or be within CERF "breeder options" from a screening by a board certified veterinary ophthalmologist.
The Canine Health Information Center (CHIC) is a centralized canine health database sponsored by the AKC/Canine Health Foundation (AKC/CHF) and OFA. The CHIC, working with participating parent clubs, provides a resource for breeders and owners of purebred dogs to research and maintain information on the health issues prevalent in specific breeds.
AKC's national breed clubs establish the breed specific testing protocols. Dogs complying with the breed specific testing requirements are issued CHIC numbers. The ACKCSC requires that, to qualify for CHIC certification, cavaliers must have a CERF eye examination, recommending that an initial CERF exam be performed at 8 to 12 weeks, with a follow up exam once the dog reaches 12 months, and annual exams thereafter until age 5 years, and every other year until age 9 years. However, all that is required to qualify for a CHIC certificate is that the breeding stock be examined by a veterinary ophthalmologist. It does not require that the results of the examination show no eye disorders.
Ocu-GLO Rx is a nutraceutical containing several natural antioxidants in a combination blend formulated specifically for canine eye health. Many veterinary ophthalmologists recommend this product to maintain healthy eyes. Even if your dog has not been diagnosed with a vision disorder, antioxidants contained in Ocu-GLO Rx are considered helpful in keeping dogs' eyes healthy.
April 2015: VetCompass analysis shows frequent diagnoses of corneal diseases in cavaliers. In an April 2015 report by UK and Australian veterinarians (Jennifer F Summers, Dan G O’Neill, David B Church, Peter C Thomson, Paul D McGreevy, David C Brodbelt), the veterinary records of 1,875 cavalier King Charles spaniels treated between 2009 and 2013 and on the database of the VetCompass animal health surveillance project, were dissected. Only 75 of the 1,875 cavaliers had a confirmed KC-registration status. They found that corneal diseases were diagnosed relatively frequently, but they could not differentiate between inherited, early forms and age-related degenerative cataracts.
January 2015: UK's Animal Health Trust announces a DNA test for corneal dystrophy in Labradors. The Animal Health Trust and UK's Kennel Club have announced a new DNA test for the genetic mutation causing macular corneal dystrophy (MCD) in Labrador retrievers. MCD is an inherited eye condition which, although painless, can cause severe visual impairment in affected dogs. The mutation for MCD is recessive, which means that only dogs that inherit two copies of the mutation will be affected. Dogs do not typically develop MCD until middle age. Now, affected and carriers Labradors can be identified through one swab test.
Dystrophy, degeneration and infiltration of the canine cornea. S.M. Crispin, K.C. Barnett. J.Small Animal Prac.;Feb. 1983;24(2):63-83. Quote: "Three conditions of the cornea in the dog are described; a form of corneal dystrophy (central/paracentral lipid dystrophy, lipidosis, lipoidosis, cholesterolosis), degeneration (fatty and calcareous degeneration) and infiltration (arcus lipoides corneae, anterior embryotoxon, pre-senile arcus). The clinical appearance, together with histopathological and ultrastructural details, are recorded. The age, sex, breed incidence and possible hereditary factors are also included. Reference is made to previous reports in the veterinary literature and the three conditions are compared with similar conditions in man."
Crystalline Stromal Dystrophy in the Cavalier King Charles Spaniel. Crispin SM, Proc Am Coll Vet Ophthalmol 17:18, 1986.
Crystalline corneal dystrophy in the dog. Histochemical and ultrastructural study. Crispin SM. Cornea. 1988;7(2):149-61.
Ocular manifestations of hyperlipoproteinaemia. S. M. Crispin. J.Small Animal Prac.;Oct. 1993;34(10):500-506. Quote: "The ocular manifestations of hyperlipoproteinaemia include visible lipaemia of ocular blood vessels, corneal opacities, lipaemic aqueous and gross infiltration of the globe itself which is easiest to observe in the peripheral cornea and uveal tract. Both primary and secondary hyperlipoproteinaemia may produce ocular signs and the ocular appearance can be characteristic of the underlying lipoprotein disorder. ... Crystalline stromal dystrophy in a Cavalier King Charles spaniel with secondary hyperlipoproteinaemia associated with Cushing’s syndome. ... Crystalline stromal dystrophy [due to] Hyperlipoproteinaemmia (raised HDL, LDL, and VLDL) [is an] ocular manifestation [of the] clinical disorder Cushing's syndrome especially in the Cavalier King Charles Spaniel."
Ocular Disorders Presumed to be Inherited in Purebred Dogs. Genetics Committee, A.C.V.O. 1999.
Control of Canine Genetic Diseases. Padgett, G.A., Howell Book House 1998, pp. 198-199, 239.
Guide to Congenital and Heritable Disorders in Dogs. Dodds WJ, Hall S, Inks K, A.V.A.R., Jan 2004, Section II(65).
Breed Predispositions to Disease in Dogs & Cats. Alex Gough, Alison Thomas. 2004; Blackwell Publ. 44-45.
Visual Morbidity in Thirty-four Families with Schnyder Crystalline Corneal Dystrophy (An American Ophthalmological Society Thesis). Jayne S. Weiss. Trans Am Ophthalmol Soc. 2007 December; 105: 616–648. Quote: "Crystalline stromal dystrophy is the commonest canine corneal lipid deposition and is relatively common in the Cavalier King Charles Spaniel."
The Eye and Systemic Disease. John Mould. 2008 WSAVA Congress. Quote: "Corneal Lipid ... Most common appearance is paracentral lipid dystrophy: ... Shelties and Cavalier King Charles spaniels."
Ophthalmic Disease in Veterinary Medicine. Charles L. Martin. Manson Publ. 2009; page 475, table 15.1. Quote: "Presumed Inherited Ocular Diseases: Table 15.1: Breed predisposition to eye disease in dogs: Cavalier King Charles Spaniel: ... Corneal dystrophy: epithelial/stromal".
Non-Ulcerative Corneal Disorders. Charlotte Keller. 2010 WSAVA Congress. Quote: "The White/Yellow/Grey/Blue Cornea: Lipid and mineral deposition in the cornea create a sparkly white, refractile appearance. The deposition of lipid in the cornea has been divided into three clinical types: 1) Crystalline stromal dystrophy--bilateral, axial or paraxial crystalline appearance without inflammation or vascularisation. The deposition of lipid in the cornea without the presence of another disease. Cavalier King Charles Spaniel, Husky Beagle, etc. 2) Lipid keratopathy (corneal lipidosis)--Arcus lipoides corneae--peripheral lesion bilateral ocular manifestation of systemic disease (hypothyroidism, systemic lipid abnormalities). 3) Corneal degeneration--primary or secondary to anterior segment disease (ulcerative keratitis, pannus). Treatment: May include the reduction of fat intake, the control of the underlying systemic diseases and control of ocular disease."
Ocular conditions affecting the brachycephalic breeds. Peter G.C. Bedford. RVC. 2010. Quote: "There are two types of disease which affect the eye of the brachycephalic breeds and both are directly or indirectly related to genetic predisposition. First and by far the commonest are those conditions which are due to be conformation of skull and are related to the exophthalmos which is the common feature of these breeds. Second there are those conditions which have been unwittingly bred into some brachycephalic breeds in the pursuit of desired breed characteristics. In this lecture I will present an overview of all the diseases that the small animal practitioner is likely to encounter in the brachycephalic breeds of pedigree dog. The fourteen breeds I have included for discussion are the Affenpinscher, Boston Terrier, Boxer, Bulldog, Cavalier King Charles and the King Charles Spaniels, (mesaticephalic) French Bulldog, Griffon Bruxellois, Japanese Chin, Lhasa Apso, Pekingese, Pug, Shih Tzu and Tibetan Spaniel. ... Corneal Lipid Dystrophy: The term applies to the characteristic cholesterol and triglyceride deposits in the superficial corneal stroma seen most commonly in the Cavalier King Charles Spaniel. It is clinically benign and seldom affects vision to any noticeable degree. ... Hereditary Cataract: Hereditary cataract is seen in the Boston Terrier and the Cavalier King Charles Spaniel. ... Microphthalmos (MoD): Again the American literature suggests that microphthalmos (MoD) may be inherited in the Cavalier King Charles Spaniel."
Breed Predispositions to Disease in Dogs & Cats (2d Ed.). Alex Gough, Alison Thomas. 2010; Blackwell Publ. 53.
A cloudy view? David L. Williams. April 2013. Quote: "What is happening in the cornea of this Cavalier King Charles Spaniel? This dog has a crystalline stromal lipid dystrophy – an inherited defect in how the keratocytes – the corneal cells - deal with lipid, leading to a deposition of lipid crystals in the centre of the cornea. It looks identical to Schnyder’s dystrophy in people as shown below, but whether the same gene mutation is present is currently unknown. In people this makes reading and driving at night difficult, but in the dog the lesion doesn’t interfere with vision (as they rarely read or drive at night!) and the lipid deposit is unlikely to develop markedly."
Cultivation of corneal epithelial cell sheets on canine amniotic membrane. Eunryel Nam, Ayaka Takahashi, Naoki Fujita, Keiko Tsuzuki, Ryohei Nishimura. Vet.Ophthalmology. July 2013;16(4):263-268. Quote: "Objective: To develop and assess canine corneal epithelial cell sheets cultivated from limbal stem cells on amniotic membrane. Procedures: Canine corneal limbal segments were obtained from six beagle dogs. Cryopreserved denuded amniotic membranes (obtained from Miniature Dachshund and Cavalier King Charles Spaniel breeds) from which the epithelial cells were removed were used as scaffolds. The limbal segments were cultured on these amniotic membranes with 3T3 feeder cells for 2 weeks. The harvested corneal epithelial cell sheets were stained with H&E for histologic analysis. The harvested sheets were analyzed immunohistochemically using a corneal epithelium-specific marker keratin 3(K3) and putative stem cell markers ABCG2, p63, and vimentin. Results: Cultivated cells from the corneal limbal tissues reached confluency in 7–8 days. The cultivated cells adhered to the denuded amniotic membrane and formed a sheet. The cultivated cell sheet was transparent and consisted of five to eight layers. K3 was observed in all layers and ABCG2, p63, and vimentin were notably present in the basal layer of the cultivated canine epithelium by immunofluorescence. Conclusions: Canine corneal epithelial cells were successfully cultivated on the canine amniotic membrane. The cultivated epithelial sheets contained putative stem cells in the basal layer and had a stratified epithelium."
The genetics of eye disorders in the dog. Cathryn S. Mellersh. Canine Genetics & Epidemiology. April 2014. Quote: "Inherited forms of eye disease are arguably the best described and best characterized of all inherited diseases in the dog, at both the clinical and molecular level and at the time of writing 29 different mutations have been documented in the scientific literature that are associated with an inherited ocular disorder in the dog. The dog has already played an important role in the identification of genes that are important for ocular development and function as well as emerging therapies for inherited blindness in humans. Similarities in disease phenotype and eye structure and function between dog and man, together with the increasingly sophisticated genetic tools that are available for the dog, mean that the dog is likely to play an ever increasing role in both our understanding of the normal functioning of the eye and in our ability to treat inherited eye disorders. This review summarises the mutations that have been associated with inherited eye disorders in the dog."
Prevalence of disorders recorded in Cavalier King Charles Spaniels attending primary-care veterinary practices in England. Jennifer F Summers, Dan G O’Neill, David B Church, Peter C Thomson, Paul D McGreevy, David C Brodbelt. Canine Genetics and Epidemiology. April 2015;2:4. Quote: "This study used large volumes of health data from UK primary-care practices participating in the VetCompass animal health surveillance project to evaluate in detail the disorders diagnosed in a random selection of over 50% of dogs recorded as Cavalier King Charles Spaniels (CKCSs). Confirmation of breed using available microchip and Kennel Club (KC) registration data was attempted. Results: In total, 3624 dogs were recorded as CKCSs within the VetCompass database of which 143 (3.9%) were confirmed as KC-registered via microchip identification linkage of VetCompass to the KC database. ... Microchip data were available in 1692 (46.7%) of the 3624 identified CKCSs. It was possible to crosslink microchip data with KC-registration details in 143 of these dogs; this represented 8.5% of all identified CKCSs with microchip data, and 3.9% of all identified CKCSs. The remaining 3481 dogs were classified as of unknown KC-registration status. The 52% randomly selected sample of all identified CKCSs totalled 1875 dogs: 1800 with unknown and 75 with confirmed KC-registration status. These 1875 dogs were seen at 109 individual clinics during the study period, including 90 (83%) Medivet and 19 (17%) Vets4Pets sites located from north-east to southern England. ...1875 dogs (75 KC registered and 1800 of unknown KC status, 52% of both groups) were randomly sampled for detailed clinical review. Clinical data associated with veterinary care were recorded in 1749 (93.3%) of these dogs. ... Median ages at first and last consultation were 4.0 and 5.25 years, respectively (ranges one month - 17.2 years for both age measures). The most frequent coat colours were Blenheim (44.3%) and tri-colour (30.8%) (Table 1). Of the 1521 dogs with more than one clinical data entry, median time contributed to the study was 1.3 years (range 1 day to 3.6 years). ... Ocular disorders, and particularly corneal diseases, were frequently recorded in study dogs. KCS was particularly frequent, with a proportion of the unspecified corneal disorders (and chronic keratitis cases) possibly also due to undiagnosed KCS. Studies suggest an autosomal recessive mode of inheritance CKCSID in the CKCS. In addition, the typical CKCS skull morphology (with large eyes and shallow eye sockets) may also pre-dispose the breed to corneal damage, exposure keratitis, conjunctival injury and subsequent irritation. Cataracts were recorded relatively frequently in study CKCSs and an inherited basis has been suggested for certain early onset cataracts in the breed. However, the current study could not differentiate between inherited, early forms and age-related degenerative cataracts. DNA screening tests (e.g. CKCSID) and British Veterinary Association (BVA)/KC health schemes (e.g., multifocal retinal dysplasia and hereditary cataract) offer opportunities to reduce population levels of certain inherited conditions through selective breeding. However, the current study indicates that eye disorders remain an important challenge for those concerned with improving the health and welfare of CKCSs. ... Further work This work highlights the value of veterinary practice based breed-specific epidemiological studies to provide targeted and evidence-based health policies. Further studies using electronic patient records in other breeds could highlight their potential disease predispositions."