Microphthalmia in Cavalier King Charles Spaniels:
Genetically Caused, Abnormally Small Eyeball
Microphthalmia (microphthalmos) is an inherited defect which is particularly common in the cavalier King Charles spaniel, according to the American College of Veterinary Ophthalmologists (ACVO).* One or both of the dog's eyes is smaller than normal, resulting in restricted vision and possible blindness. (Note: the CKCS puppy at the right does not have microphthalmia.)
* See also, Ophthalmic Disease in Veterinary Medicine.
There is no treatment for microphthalmia.
All CKCSs should be examined at least annually by a board certified veterinary ophthalmologist. They are listed on the American College of Veterinary Ophthalmologists website.
The Genetics Committee of the ACVO recommends that CKCSs affected with microphthalmia not be bred. The Canine Inherited Disorders Database also recommends that cavaliers suffering from microphthalmia not be bred, nor should the dog's parents and any of its siblings.
The Cavalier King Charles Spaniel Club, USA recommends that, prior to breeding any cavalier, the dog have a normal rating from a screening by a board certified veterinary ophthalmologist.
All CKCS breeding stock should be examined by board certified veterinary ophthalmologists and cleared by the veterinarians for microphthalmia.
Ocu-GLO Rx is a nutraceutical containing several natural antioxidants in a combination blend formulated specifically for canine eye health. Many veterinary ophthalmologists recommend this product to maintain healthy eyes. Even if your dog has not been diagnosed with a vision disorder, antioxidants contained in Ocu-GLO Rx are considered helpful in keeping dogs' eyes healthy.
November 2016: Cavalier eye sizes are large for small dogs but fit in the medium dog group. In a November 2016 article, UK ophthalmologists (Carolin L. H. Chiwitt, Stephen J. Baines, Paul Mahoney, Andrew Tanner, Christine L. Heinrich, Michael Rhodes, Heidi J. Featherstone) found that the size of the eyes of the cavalier King Charles spaniel, a small dog, was larger than other small dogs and fit within the eye size of medium sized dogs. The researchers measured the eye sizes of 100 dogs in ten breeds, incuding 10 cavalier King Charles spaniels.
The researchers used both B-mode ocular ultrasound and computed tomography (CT) to do so in a procedure called "ocular biometry", which is the measurement of the dimensions of the eye, its components, and their interrelationships. They divided the 100 dogs into three size groups -- small, medium, and large based upon the UK Kennel Club assignments -- and placed the CKCS in the small dog group. They measured eye length, width, and height using the both of the devices -- ultrasound and CT.
They found that the CKCS had a relatively large eye for the small breed group, and there was no significant difference between the CKCS eye and those in the medium breed group. They also found that their measurements using both B-mode ultrasound and CT can be applied for the diagnosis of microphthalmos and buphthalmos.
September 2015: Italian researchers find retinal dysplasia and microphthalmia in a family of cavaliers. In a September 2015 publication of an oral abstract presented before the European College of Veterinary Ophthalmologists in May 2015, a team of Italian ophthalmologists (Luca Mertel [right], MG Baldini, E Moretti, SP Marelli, A Picchi, M Polli) report on the parents and littermates of a family of cavalier King Charles spaniels. The ruby dam "was affected by multiple distichia and bilateral peripheral tapetal multifocal retinal dysplasia." The black-&-tan sire "had unilateral iris to iris persistent pupillary membranes." Pup #1 (ruby female) "had bilateral multifocal and geographical retinal dysplasia". Pup #2 (black-&-tan male) "showed bilateral microphthalmia".. Pup #3 (black-&-tan male) "had bilateral iris to iris persistent pupillary membranes and unilateral right multifocal and geographical horseshoe-shaped retinal dysplasia." They concluded:
"Microphthalmia with lens dysmorphogenesis and normal looking fundi seems to be a feature in the CKCS. Littermates may be affected with varies forms of retinal dysplasia, as in the Akita and the Chow Chow."
October 2013: Dr. Peter Bedford reports microphthalmos and congenital cataracts are linked in CKCSs. In the Autumn 2013 issue of EJCAP Online for the Federation of European Companion Animal Veterinary Associations (FECAVA), UK ophthalmologist Dr. Peter G.C. Bedford summarizes the research in hereditary eye disorders. He states that congenital nuclear cataract may accompany microphthalmos, persistence of remnant pupillary membrane (PPM) and retinal dysplasia in the Cavalier King Charles Spaniel.
Posterior lenticonus, cataracts and microphthalmia: congenital ocular defects in the Cavalier King Charles Spaniel. Narfström K, Dubielzig R. J. Sm. Anim. Pract. 1984; 25: 669–677. Quote: Eleven cases of congenital ocular defects were found in the screening of 144 Cavalier King Charles Spaniels in Sweden. Mainly posterior lenticonus, cataracts and microphthalmia were observed in the affected dogs, most of which were interrelated. Pathology was obtained from one of the cases demonstrating bilateral posterior lens capsule rupture with an unusual cellular reaction of the exposed lens material. ... The lenticular abnormalities found in the Cavalier King Charles Spaniel breed of dog mainly affect the nucleus, posterior cortex and the posterior capsule. These defects, together with an intact posterior lens capsule, indicate an early developmental insult in the formation of the foetal lens. Numerous theories have been proposed to explain posterior lenticonus formation. Most of the histologic evidence supports a congenital defect involving an abnormal embryonic remnant in the epithelial cell proliferation before the lens capsule forms or a hyperplasia of the lens accompanied by a thinning of the capsule over the defect. In the Cavalier dog the latter explanation seems to be the most likely. Persistence of hyaloid vessels or remnants of these is further evidence of an early developmental aberration. Microphthalmia is a common finding in conjunction with other severe ocular malformations which were also found in the present study.
Hereditary cataract in the Miniature Schnauzer. K. C. Barnett. J.Small Animal Prac.; Nov. 1985;26(11):635-644. Quote: "Posterior lenticonus, cataract and microphthalmos, as reported here and in the USA (Gelatt et al., 1983b) has also been reported in the Cavalier King Charles Spaniel in Sweden (Narfstrom & Dubielzig, 1984)."
Control of Canine Genetic Diseases. Padgett, G.A., Howell Book House 1998, pp. 198-199, 241.
Ocular Disorders Presumed to be Inherited in Purebred Dogs. Genetics Committee, A.C.V.O. 1999.
Guide to Congenital and Heritable Disorders in Dogs. Dodds WJ, Hall S, Inks K, A.V.A.R., Jan 2004, Section II(199).
Breed Predispositions to Disease in Dogs & Cats. Alex Gough, Alison Thomas. 2004; Blackwell Publ. 44-45.
Ophthalmic Disease in Veterinary Medicine. Martin C.L. Manson Publ. 2005.
Canine Inherited Disorders Database: http://ic.upei.ca/cidd/disorder/microphthalmia-ocular-dysgenesis
Ophthalmic Disease in Veterinary Medicine. Charles L. Martin. Manson Publ. 2009; page 475, table 15.1. Quote: "Presumed Inherited Ocular Diseases: Table 15.1: Breed predisposition to eye disease in dogs: Cavalier King Charles Spaniel: ... Microphthalmia with multiple ocular anomalies".
Ocular conditions affecting the brachycephalic breeds. Peter G.C. Bedford. 2010. RVC. Quote: "There are two types of disease which affect the eye of the brachycephalic breeds and both are directly or indirectly related to genetic predisposition. First and by far the commonest are those conditions which are due to be conformation of skull and are related to the exophthalmos which is the common feature of these breeds. Second there are those conditions which have been unwittingly bred into some brachycephalic breeds in the pursuit of desired breed characteristics. In this lecture I will present an overview of all the diseases that the small animal practitioner is likely to encounter in the brachycephalic breeds of pedigree dog. The fourteen breeds I have included for discussion are the Affenpinscher, Boston Terrier, Boxer, Bulldog, Cavalier King Charles and the King Charles Spaniels, (mesaticephalic) French Bulldog, Griffon Bruxellois, Japanese Chin, Lhasa Apso, Pekingese, Pug, Shih Tzu and Tibetan Spaniel. ... Corneal Lipid Dystrophy: The term applies to the characteristic cholesterol and triglyceride deposits in the superficial corneal stroma seen most commonly in the Cavalier King Charles Spaniel. It is clinically benign and seldom affects vision to any noticeable degree. ... Hereditary Cataract: Hereditary cataract is seen in the Boston Terrier and the Cavalier King Charles Spaniel. ... Microphthalmos (MoD): Again the American literature suggests that microphthalmos (MoD) may be inherited in the Cavalier King Charles Spaniel."
Genetic Connection: A Guide to Health Problems in Purebred Dogs, Second Edition. Lowell Ackerman. July 2011; AAHA Press; pg 169. Quote: "In the ... Cavalier King Charles spaniel ... microphthalmia is associated with multiple ocular anomalies."
Ocular Disorders Presumed to be inherited in purebred dogs. Genetics Committee of the American College of Veterinary Ophthalmologists. Blue Book 6th Ed. 2013. pp. 241-247. Quote: "Cavalier King Charles Spaniel: Disorder: A. Microphthalmia with multiple ocular defects. Inheritance: Not defined."
Hereditary Ocular Disease in the dog. Peter G C Bedford. EJCAP Online, Genetic/Hereditary Disease and Breeding. Autumn 2013;233(3):23-41. Quote: "Congenital inherited disease: ... Congenital Cataract: Cataract is defined as any opacity of the lens and/or its capsule. Congenital inherited cataract always involves the central embryonic and foetal nuclear portion of the lens, whilst those lens fibres which make up the cortex usually remain transparent. Thus congenital nuclear cataract is often described as stationary, with the effect on the dog’s sight being dictated by the extent of the opacity. Such patients may be managed long term by using long acting mydriatic drugs, but when cortical involvement occurs lens removal may prove necessary. The condition occurs as a recessive trait in the Miniature Schnauzer and it may become established as an inherited entity in the Old English Sheepdog, the Golden Retriever and the West Highland White Terrier unless breeders respond adequately to early findings in these breeds. Congenital nuclear cataract may also accompany microphthalmos, PPM and retinal dysplasia in breeds like the Bloodhound, the Cavalier King Charles Spaniel, the Cocker Spaniel, the Dobermann, the Golden Retriever, the Old English Sheepdog, the Rottweiler, the Rough Collie, the Standard Poodle and the West Highland White Terrier as part of a multi-ocular defect (MOD).
Familial retinal dysplasia and microphthalmia with lens abnormalities in the cavalier King Charles spaniel (CKCS). L Mertel, MG Baldini, E Moretti, SP Marelli, A Picchi, M Polli. Vet. Opthalmology. September 2015;18(5):E5. Quote: "Purpose: To report congenital hereditary eye disorders including microphthalmia with cataract, posterior lenticonus and retinal dysplasia in a family of CKCS. The clinical ﬁndings of bilateral multifocal retinal dysplasia in a dam led to the ocular examination of the stud and the litter. Multiple congenital ocular anomalies of this family are described. Methods: All dogs were examined following the ECVO eye scheme and the horizontal corneal diameter was measured (mm) in the awake animals using a caliper. Results: The dam (34 months, ruby) was affected by multiple distichia and bilateral peripheral tapetal multifocal retinal dysplasia. The sire (27 months, black and tan) had unilateral iris to iris persistent pupillary membranes. Pup #1 (female, 2 months, ruby) had bilateral multifocal and geographical retinal dysplasia characterized by a horseshoe-shaped area in the right dorsolateral tapetal periphery and a circular dysplastic lesion in the left dorsomedial tapetal periphery. Pup #2 (male, 2 months, black and tan) showed bilateral micro-phthalmia (11 mm OU) with nuclear, cortical and posterior capsular cataract and right posterior lenticonus. Pup #3 (male, 2 months, black and tan) had bilateral iris to iris persistent pupillary membranes and unilateral right multifocal and geo-graphical horseshoe-shaped retinal dysplasia. Conclusion: Microphthalmia with lens dysmorpho-genesis and normal looking fundi seems to be a feature in the CKCS. Littermates may be affected with varies forms of retinal dysplasia, as in the Akita and the Chow Chow."
Ocular biometry by computed tomography in different dog breeds. Carolin L. H. Chiwitt, Stephen J. Baines, Paul Mahoney, Andrew Tanner, Christine L. Heinrich, Michael Rhodes, Heidi J. Featherstone. Vet. Ophth. November 2016. Quote: Objective: To (i) correlate B-mode ocular ultrasound (US) and computed tomography (CT) (prospective pilot study), (ii) establish a reliable method to measure the normal canine eye using CT, (iii) establish a reference guide for some dog breeds, (iv) compare eye size between different breeds and breed groups, and (v) investigate the correlation between eye dimensions and body weight, gender, and skull type (retrospective study). Procedure: B-mode US and CT were performed on ten sheep cadaveric eyes. CT biometry involved 100 adult pure-bred dogs with nonocular and nonorbital disease, representing eleven breeds [including ten cavalier King Charles spaniels]. Eye length, width, and height were each measured in two of three planes (horizontal, sagittal, and equatorial). Results: B-mode US and CT measurements of sheep cadaveric eyes correlated well (0.70–0.71). The shape of the canine eye was found to be akin to an oblate spheroid (a flattened sphere). A reference guide was established for eleven breeds. Eyes of large breed dogs (GSD, Labrador Retriever, Boxer) were significantly larger than those of medium ((Border Collie, SBT, Cocker Spaniel, ESS) and small breed dogs (CKCS, Border Terrier, JRT, WHWT) (P < 0.01), and eyes of medium breed dogs were significantly larger than those of small breed dogs (P < 0.01). ... There was no significant difference between the CKCS eye (a small breed) and the medium breed group. ... Eye size correlated with body weight (0.74–0.82) but not gender or skull type. Conclusions: Computed tomography is a suitable method for biometry of the canine eye, and a reference guide was established for eleven breeds. Eye size correlated with breed size and body weight. ... The CKCS had a relatively large eye for the small breed group. ... Because correlation between B-mode US and CT was shown, the obtained values can be applied in the clinical setting, for example, for the diagnosis of microphthalmos and buphthalmos.