Genetic Eye Disorders in
Cavalier King Charles Spaniels

The cavalier King Charles spaniel has more than its fair share of severe genetic diseases afflicting the eye.* A 2008 study of cavaliers conducted by the Canine Eye Registration Foundation showed that an average of 28% of all CKCSs evaluated had eye problems.

* See, American College of Veterinary Ophthalmologists (ACVO) and Ophthalmic Disease in Veterinary Medicine.

They include hereditary cataracts, corneal dystrophy, distichiasis, dry eye syndrome, entropion, microphthalmia, progressive retinal degeneration, and retinal dysplasia, all of which are discussed on this website. Other hereditary eye disorders, of more minor nature, are not discussed.

Some cavaliers may develop other eye disorders which are considered genetic in other breeds. These include "prolapsed gland of nictitans", also known as "cherry eye". The nictitating membrane is the dog's third eyelid, a small triangular flap of cartilage in the inner corner of the eye, which covers a tear gland. Breeds predisposed to cherry eye include the Beagle, Boston terrier, bulldogs, Cocker spaniel, and Lhasa Apso.  include the Beagle, Boston terrier, bulldogs, Cocker spaniel, and Lhasa Apso.

Cavalier King Charles Spaniel with Cherry EyeIf and when the gland should flip upward (prolapses), it becomes inflamed and protrudes and bulges over the third eyelid, giving the appearance of a reddish cherry. (See a CKSC's eye with cherry eye, at left.) While the appearance of cherry eye is disturbing, it usually is not painful to the dog. Nevertheless, cherry eye should be treated promptly, because it may lead to chronic irritation of the cornea, conjunctiva, and dry eye (keratoconjunctivitis sicca or KCS).

Cherry eye usually requires some surgical treatment. In some mild instances, the ophthalmologist may be able to relocate the gland into its proper position without surgery. Replacing the gland is almost always necessary. Unfortunately, a high percentage of gland-replacement surgeries result in the loss of the gland’s tear-producing ability, causing dry eye.

In our Veterinary Resources section below, we also include citations to veterinary journal articles on other vision disorders for which cavaliers have been treated, including  reticulosis and Ehlers-Danlos syndrome.

In many instances, the eye disorders CKCSs experience may be attributed to the brachycephalic shape of their heads. All cavaliers should be examined at least annually by a board certified veterinary ophthalmologist. They are listed on this webpage of the website of the American College of Veterinary Ophthalmologists.

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Ocu-GLO RxWhat You Can Do:

 Ocu-GLO Rx is a nutraceutical containing several natural antioxidants in a combination blend formulated specifically for canine eye health. Many veterinary ophthalmologists recommend this product to maintain healthy eyes. Even if your dog has not been diagnosed with a vision disorder, antioxidants contained in Ocu-GLO Rx are considered helpful in keeping dogs' eyes healthy.

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Veterinary Resources:

Reticulosis of the eyes and the central nervous system in a dog. NL Garmer, P Naeser, AJ Bergman. J.Small Animal Prac.; Jan. 1981;22(1):39-45. Quote: "Bilateral optic neuritis was diagnosed in a 5-year old dog, which had been blind for two days. ... CASE REPORT A 5-year old, 10 kg, male Cavalier King Charles Spaniel was examined because the dog had appeared blind for two days. ... Vision returned after corticosteroid therapy. Two weeks after the end of this treatment the dog became blind again and, in addition, showed ataxia. Post-mortem examination revealed changes in both the central nervous system and the eyes. The histopathological changes observed were consistent with those of reticulosis.

Ehlers-Danlos syndrome in a dog: ocular, cutaneous and articular abnormalities. KC Barnett, BD Cottrell. J.Small Animal Prac. - Journal of Small Animal Practice; Oct. 1987;28(10):941-946. Quote: "Ehlers-Danlos syndrome (EDS) is an hereditary connective tissue disease in man in which the skin is easily torn. A similar condition has been described in dogs and other animals. This case report records a case in the United Kingdom in which the whole syndrome was exhibited: skin fragility, joint laxity and ocular signs of bilateral lens luxation, cataract and corneal oedema. It is the first report of ocular signs in EDS in the dog and joint laxity has been reported only rarely. ... A crossbred bitch (Cavalier King Charles Spaniel x Rorder Collie bitch) was presented at the age of 12 months for investigation of failing vision. ... The case reported here was a Cavalier King Charles Spaniel x Border Collie; neither breed has previously been implicated."

Angiostrongylus vasorum in the anterior chamber of a dog's eye. M. C. A. King, R. M. R. Grose, G. Startup. J.Small Animal Prac.;June 1994;35(6):326-328. Quote: "An unusual case of Angiostrongylus vasorum infestation occurred in a three-year-old female cavalier King Charles spaniel. The dog presented with signs consistent with right otitis interna, followed by the appearance of a free-swimming nematode in the anterior chamber of the right eye. The dog died of acute heart failure before surgical removal of the parasite was possible. Post mortem examination confirmed the presence of large numbers of worms in the pulmonary artery and right ventricle. These worms were identified histologically as A vasorum."

Control of Canine Genetic Diseases. Padgett, G.A., Howell Book House 1998, pp. 198-199, 239.

Ocular Disorders Presumed to be Inherited in Purebred Dogs. Genetics Committee, A.C.V.O. 1999.

Guide to Congenital and Heritable Disorders in Dogs. Dodds WJ, Hall S, Inks K, A.V.A.R., Jan 2004, Section II(88).

Breed Predispositions to Disease in Dogs & Cats. Alex Gough, Alison Thomas. 2004; Blackwell Publ. 44-45.

Ophthalmic Disease in Veterinary Medicine. Charles L. Martin. Manson Publ. 2009; page 475, table 15.1. Quote: "Presumed Inherited Ocular Diseases: Table 15.1: Breed predisposition to eye disease in dogs: Cavalier King Charles Spaniel: ... ."

Breed Predispositions to Disease in Dogs & Cats (2d Ed.). Alex Gough, Alison Thomas. 2010; Blackwell Publ. 53.

Ocular conditions affecting the brachycephalic breeds. Peter G.C. Bedford. 2010. RVC. Quote: "There are two types of disease which affect the eye of the brachycephalic breeds and both are directly or indirectly related to genetic predisposition. First and by far the commonest are those conditions which are due to be conformation of skull and are related to the exophthalmos which is the common feature of these breeds. Second there are those conditions which have been unwittingly bred into some brachycephalic breeds in the pursuit of desired breed characteristics. In this lecture I will present an overview of all the diseases that the small animal practitioner is likely to encounter in the brachycephalic breeds of pedigree dog. The fourteen breeds I have included for discussion are the Affenpinscher, Boston Terrier, Boxer, Bulldog, Cavalier King Charles and the King Charles Spaniels, (mesaticephalic) French Bulldog, Griffon Bruxellois, Japanese Chin, Lhasa Apso, Pekingese, Pug, Shih Tzu and Tibetan Spaniel. ... Corneal Lipid Dystrophy: The term applies to the characteristic cholesterol and triglyceride deposits in the superficial corneal stroma seen most commonly in the Cavalier King Charles Spaniel. It is clinically benign and seldom affects vision to any noticeable degree. ... Hereditary Cataract: Hereditary cataract is seen in the Boston Terrier and the Cavalier King Charles Spaniel. ... Microphthalmos (MoD): Again the American literature suggests that microphthalmos (MoD) may be inherited in the Cavalier King Charles Spaniel."

Ocular Disorders Presumed to be inherited in purebred dogs. Genetics Committee of the American College of Veterinary Ophthalmologists. Blue Book 6th Ed. 2013. pp. 241-247.

Blindness: A Step-by-Step Approach to Diagnosis. Alison Clode. NAVC Clinician's Brief. April 2014;14-15.

The genetics of eye disorders in the dog. Cathryn S. Mellersh. Canine Genetics & Epidemiology. April 2014. Quote: "Inherited forms of eye disease are arguably the best described and best characterized of all inherited diseases in the dog, at both the clinical and molecular level and at the time of writing 29 different mutations have been documented in the scientific literature that are associated with an inherited ocular disorder in the dog. The dog has already played an important role in the identification of genes that are important for ocular development and function as well as emerging therapies for inherited blindness in humans. Similarities in disease phenotype and eye structure and function between dog and man, together with the increasingly sophisticated genetic tools that are available for the dog, mean that the dog is likely to play an ever increasing role in both our understanding of the normal functioning of the eye and in our ability to treat inherited eye disorders. This review summarises the mutations that have been associated with inherited eye disorders in the dog."

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