Heart mitral valve disease (MVD) is a terminal illness which may afflict over half of all cavalier King Charles spaniels by the age of 5 years and nearly all Cavaliers by age 10 years. It is CKCSs' leading cause of death.
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- February 2018 -- French researchers report study of two CKCSs with PSOM which displayed lip drooling and facial paralysis.
- February 2018 -- Dr. Williams finds that dry eye is an immune-mediated T cell-dominated condition.
- February 2018 -- Mississippi State University researchers compare SNAP cPL, Spec cPL, VetScan cPL, and Precision PSL enzyme assays for accuracy in diagnosing pancreatitis in dogs.
- January 2018 -- UK study finds MRI images can assess oral cavity landmarks and that soft-palate-to-epiglottis overlap is directly proportionate to degree of brachcephalia in dogs.
- January 2018 -- Korean surgeons successfully use Lyoplant as a collagen implant dural substitute in foramen magnum decompression surgery.
- January 2018 -- Belgian questionnaire study of 114 CKCS owners shows they are most concerned about MVD and CM/SM in selecting dogs.
- January 2018 -- UK study of 486 dogs shows three years between core vaccine boosters provide long-lived immunity.
- January 2018 -- UK cardiologists find increases in certain white blood cells are tied to MVD-dogs in heart failure.
- January 2018 -- Dr. Brian Scansen explains the vital importance of home respiratory rate monitoring of MVD-affected dogs.
- December 2017 -- Purina patent application claims coconut oil ingredient reverses MVD echo measurements.
- December 2017 -- Human and cavalier study finds serotonin 5HT receptors contribute to MVD progression, and the drug LY 272015 may offset the progression.
- December 2017 -- Brazilian researchers find relationship between inflammatory secretions and MVD progression.
- December 2017 -- Romanian researchers find single sets of x-ray measurements of heart size alone are unreliable in diagnosing enlargement.
- December 2017 -- Dr. David Williams reports on current concepts of dry eye diagnosis and treatment.
- December 2017 -- UK researchers find significant correlations using flexed-neck position MRI scans of cavaliers and other brachycephalic dogs with and without CM.
- December 2017 -- OUR BLOG: Did the EPIC Study investigators intentionally enroll Stage B1 cavalier King Charles spaniels in their Stage B2 trial?
- December 2017 -- Dr. David Williams reports that Rose Bengal staining indicates tear production level of dry-eye cavaliers.
- Decenber 2017 -- USA cardiologist Dr. Jason Arndt rejects EPIC Study recommendation to treat mild enlargement with pimobendan.
- December 2017 -- Dr. Susan K. (Penny) Knowler's doctoral thesis has been published.
- December 2017 -- UK syringomyelia researchers report results of testing SM-affected cavaliers for negative attitudes toward stimuli.
- December 2017 -- Ohio State cardiologists find systolic function of right ventricle in MVD-affected dogs is affected by the stage of MVD.
- December 2017 -- Cardiologists strike out in search for the genetic cause of MVD in cavaliers.
- December 2017 -- EPIC Study's longitudinal analysis has significant surprises for the investigators.
- December 2017 -- NEW WEBPAGE: Liver / Hepatic Disorders of the Cavalier King Charles Spaniel.
- December 2017 -- An ACE gene polymorphism may explain why ACE-inhibitors are less effective in MVD-affected cavaliers.
- December 2017 -- Japanese surgeons report successful, complicated mitral valve repair of a mixed-breed Chihuahua using Gore-Tex e-PTFE sutures.
- December 2017 -- Bulgarian cardiologist finds echo marker of LA/Ao ratio and x-ray VHS values cannot be used to initiate MVD therapy.
- December 2017 -- NEW WEBPAGE: Exocrine Pancreatic Insufficiency (EPI) and the Cavalier King Charles Spaniel.
- November 2017 -- Austrian researchers suspect cavaliers may have an impaired immunity to Pneumocystis infection.
- November 2017 -- UK researchers find phantom scratching in CM/SM cavaliers is due to a large syrinx at the superficial dorsal horn.
- November 2017 -- OUR BLOG: Why are cardiology researchers inventing bogus definitions of species-wide heart enlargement to test risky drugs?
- November 2017 -- USA cardiologists study 247 records of MVD-affected dogs to determine what VHS values also equated to EPIC Study echo criteria.
- November 2017 -- Study of 88 MVD-affected dogs under anesthesia during dental procedures finds no increased risk for complications.
- November 2017 -- NC State study of cavaliers with CM and CM/SM finds phantom scratching most common sign and CM-only dogs showing classic pain signs.
- October 2017 -- USA cardiologists find cavaliers with variant of the angiotensin-converting enzyme (ACE) gene have lower ACE activity reaction to mitral valve disease.
- October 2017 -- Cavalier with facial nerve paralysis is successfully treated with laser treatment at acupuncture points.
- October 2017 -- OUR BLOG: The EPIC Study’s three heart “enlargement” parameters are arbitrary and unsupported by their cited authorities!
- October 2017 -- Colorado cardiologist Jeremy Orr advocates prescribing pimobendan to MVD-affected dogs even without heart enlargement.
- October 2017 -- In a French study of 205 dogs with middle ear disorders, only cavaliers had PSOM.
- October 2017 -- Korean study of echocardiograph measurements and biomarkers lists the most reliable parameters for detecting MVD and heart failure.
- October 2017 -- Cavaliers were at highest risk of severe reaction to incompatible blood transfusions, in Italian study.
- October 2017 -- The TEST Study finds torasemide is more effective than furosemide in treating MVD-affected dogs in heart failure over a short term.
- September 2017 -- US and Dutch cardiologists measure mitral valve regurgitation using real-time three-dimensional transthoracic echocardiography (RT3DE).
- September 2017 -- Cardiologists Borgarelli and Menciotti caution against generalizing the narrow EPIC Study results.
- September 2017 -- Polish cardiologists suggest that echocardiography should be used to detect MVD regurgitation which does not produce murmurs.
- September 2017 -- Chiari-like malformation is found in 100% of 1,020 cavaliers in Belgium and the Netherlands and syringomyelia in 39%.
- September 2017 -- PSOM is found in up to 38% of CKCSs examined in a Netherlands/Belgium study of 1,000+ dogs.
- September 2017 -- Dr. David Williams reports patterns in dried tears differ markedly between dogs with normal eyes and those with dry eye.
- September 2017 -- OUR BLOG: Telemedicine is the answer, when no cardiologist is nearby.
- September 2017 -- OUR BLOG: Cardiac Education Group doubles down on prescribing Vetmedin (pimobendan) to dogs without enlarged hearts.
- September 2017 -- Widespread syringomyelia and craniocervical junction abnormalities are found in study of 53 Chihuahuas.
- August 2017 -- Dr. Martin Schmidt finds cerebral blood flow is reduced in CKCS with ventriculomegaly and may be a form of hydrocephalus.
- August 2017 -- Texas A&M's veterinary cardiology dept. needs young CKCSs for free echo study of healthy mitral valves.
- August 2017 -- University of Minnesota's Canine Genetics Laboratory offers a genetic test for CKCS xanthinuria.
- August 2017 -- French surgeons test an oral approach to installing tympanostomy tubes in cavaliers with PSOM.
- July 2017 -- Neurologist Dr. Coates of Univ. of Missouri needs DM-affected dogs for clinical trial.
- July 2017 -- Spironlactone study of MVD-affected dogs in Stage B2 proves nothing new.
- July 2017 -- Sildenafil (Viagra) beats out enalapril in improving heart rate variability in Stage B MVD-affected dogs.
Veterinary specialists have designed breeding guidelines to eliminate early-onset mitral valve disease in cavalier King Charles spaniels.
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Syringomyelia (SM) is reported to be "very widespread" in the cavalier King Charles spaniel breed. Syringomyelia is a disorder of the brain and spinal cord, which may cause severe head and neck pain and possible paralysis.
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Hip dysplasia reportedly afflicts up to one out of every four cavalier King Charles spaniels. It is a genetic disease which can cause the dogs pain and debilitation.
Low blood platelet counts in cavaliers usually are not a health problem. Many veterinarians are misled by low platelet counts to wrongly diagnose anemia or other serious disorders.
The size and shape of its head can cause serious breathing problems for the cavalier King Charles spaniel. Elongated soft palates, stenotic nares, everted laryngeal saccules, and laryngeal collapse are inherited developmental defects in the breed.
Cavalier King Charles spaniels appear predisposed to develop cerebellar infarcts, or strokes.
Cavaliers are predisposed to a form of congenital deafness, which is present at birth, and also to a progressive hereditary hearing loss, which usually begins during puppyhood and worsens, or progresses, until the dog is completely deaf, usually between the ages of three and five years.
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